Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.

推荐稀释比 WB:1/500-1/1000

Western blot analysis of Notch1 in C6, Hela lysates using Notch1 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。