The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3).

推荐稀释比 WB:1/500-1/1000

Western blot analysis of MADH7/SMAD7 in lysate of U87MG using MADH7/SMAD7 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。