Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors.

Western

Western blot analysis of PI3-Kinase catalytic subunit alpha in Jurkat,MCF-7,Raw264.7 lysates using PI3-Kinase catalytic subunit alpha antibody.

Western

Western blot analysis of PI3 Kinase p110 alpha in Jurkat lysates using PI3 Kinase p110 alpha antibody.

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