Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

Immunocytochemistry

Immunocytochemistry analysis of Fas (green) in HL-60 using Fas antibody,and DAPI(blue).

Western

Western blot analysis of Fas in Hela, Jurkat lysates using Fas antibody.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human lung cancer tissue using Fas antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.