This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation.

Western

Western blot analysis of AIF in K562 lysates using AIF antibody.

Immunofluorescence

Immunofluorescence analysis of AIF in Hela using AIF antibody.