_{Retinoic acid又称维生素甲酸、维A酸、维甲酸、视黄酸、视黄醇等，是维生素A的代谢中间产物，以及Retinoic acid receptor和Retinoid X receptor的配体，可诱导细胞分化和细胞凋亡，在细胞生长、分化和器官形成上发挥关键作用，在上皮代谢和骨的生长上也起到重要作用。Retinoic acid对PPARα的Kd值为103 nM，PPARβ/δ的Kd值为17 nM，对RARα/β/γ的IC50值为14 nM。}

参考文献

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[3]. Uchida G, et al. Tretinoin reverses upregulation of matrix metalloproteinase-13 in human keloid-derived fibroblasts. Exp Dermatol. 2003;12 Suppl 2:35-42.

[4]. Wu L, et al. Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis. PLoS One. 2016 Apr 14;11(4).

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