IRE1α kinase-IN-1是一种高选择性IRE1α(ERN1)抑制剂，对IRE1α的选择性比IRE1β高100倍。它能抑制内质网应激诱导的IRE1α寡聚和自磷酸化，并抑制其RNase活性。

[1] Colombano G, Caldwell JJ, Matthews TP, Bhatia C, Joshi A, McHardy T, et al. Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease. J Med Chem. 2019;62(5):2447-2465.