BTX161是一种沙利度胺类似物和有效的CKIα降解剂。相较于来那度胺，它在人AML细胞中展现出更强的CKIα降解能力，并能激活DNA损伤反应（DDR）与p53通路，同时稳定p53的拮抗剂MDM2。

/

-25~-15℃避光保存，有效期3年。

[1] Minzel W, Venkatachalam A, Fink A, Hung E, Brachya G, Burstain I, Shaham M, Rivlin A, Omer I, Zinger A, Elias S, Winter E, Erdman PE, Sullivan RW, Fung L, Mercurio F, Li D, Vacca J, Kaushansky N, Shlush L, Oren M, Levine R, Pikarsky E, Snir-Alkalay I, Ben-Neriah Y. Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell. 2018 Sep 20;175(1):171-185.e25. doi: 10.1016/j.cell.2018.07.045. Epub 2018 Aug 23. PMID: 30146162; PMCID: PMC6701634.