IACS-010759是口服有效的线粒体氧化磷酸化复合物I（OXPHOS）抑制剂，在依赖OXPHOS的脑癌和急性髓性白血病（AML）模型中能抑制细胞增殖并诱导凋亡，具有用于复发/难治性AML及实体瘤研究的潜力。

[1] Marina Protopopova, Madhavi Bandi, Jennifer Bardenhagen, Christopher Bristow, Christopher Carroll, Edward Chang, Ningping Feng, Jason Gay, Mary Geck Do, Jennifer Greer, Marina Konopleva, Polina Matre, Zhijun Kang, Gang Liu, Florian Muller, Timothy Lofton, Timothy McAfoos, Yuting Sun, Melinda Smith, Jay Theroff, Yuanqiang Wu, Lynda Chin, Giulio Draetta, Philip Jones, Carlo Toniatti, M. Emilia Di Francesco, Joseph R. Marszalek; Abstract 4380: IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities. Cancer Res 1 August 2015; 75 (15_Supplement): 4380.