This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme.

Western

Western blot analysis of XIAP in Human normal kidney lysates using XIAP antibody

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human tonsil using XIAP antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.