Flumethasone (Flumetasone)是一种口服有效、高选择性且高效的糖皮质激素受体(GR)激动剂。它能激活GR,从而抑制NF-κB介导的促炎细胞因子（如 TNF-α、IL-1β）生成,并促进抗炎基因（如 IL-10）的表达,同时调节代谢酶（如酪氨酸转氨酶）活性。该化合物在炎性疾病、癌症及内分泌调节研究方面具有潜力。
|
英文别名 (English Synonym) |
Flumethasone |
|
中文名称 (Chinese Name) |
氟米松 |
|
靶点 (Target) |
Glucocorticoid Receptor |
|
通路 (Pathway) |
GPCR/G protein |
|
CAS号 (CAS NO.) |
2135-17-3 |
|
分子式 (Formula) |
C22H28F2O5 |
|
分子量 (Molecular Weight) |
410.45 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Zhou Y, Zhou Y, Wang K, Li T, Yang M, Wang R, Chen Y, Cao M, Hu R. Flumethasone enhances the efficacy of chemotherapeutic drugs in lung cancer by inhibiting Nrf2 signaling pathway. Cancer Lett. 2020 Apr 1,474:94-105. doi: 10.1016/j.canlet.2020.01.010. Epub 2020 Jan 16. PMID: 31954771.[2]Blake RL. Flumethasone induction of liver tyrosine aminotransferase activity in inbred strains and obese mutant mice. Biochem Pharmacol. 1970 May,19(5):1803-15. doi: 10.1016/0006-2952(70)90174-7. PMID: 4398019.
