Medetomidine hydrochloride是一种口服有效的α2肾上腺素受体激动剂,具有镇静和镇痛作用。它通过激活血管上的α2肾上腺素能受体,引起外周血管收缩。
|
英文别名 (English Synonym) |
Medetomidine HCl |
|
中文名称 (Chinese Name) |
盐酸美托咪定 |
|
靶点 (Target) |
Adrenergic Receptor |
|
通路 (Pathway) |
GPCR/G protein |
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CAS号 (CAS NO.) |
86347-15-1 |
|
分子式 (Formula) |
C13H16N2·HCl |
|
分子量 (Molecular Weight) |
236.74 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Lind U, Alm Rosenblad M, Hasselberg Frank L, Falkbring S, Brive L, Laurila JM, Pohjanoksa K, Vuorenpää A, Kukkonen JP, Gunnarsson L, Scheinin M, Mårtensson Lindblad LG, Blomberg A. Octopamine receptors from the barnacle balanus improvisus are activated by the alpha2-adrenoceptor agonist medetomidine. Mol Pharmacol. 2010 Aug,78(2):237-48. doi: 10.1124/mol.110.063594. Epub 2010 May 20. PMID: 20488921.[2]Kuo WC, Keegan RD. Comparative cardiovascular, analgesic, and sedative effects of medetomidine, medetomidine-hydromorphone, and medetomidine-butorphanol in dogs. Am J Vet Res. 2004 Jul,65(7):931-7. doi: 10.2460/ajvr.2004.65.931. PMID: 15281651.
