Darunavir Ethanolate (TMC114 Ethanolate)是一种高效的 HIV-1 蛋白酶抑制剂,可用于 HIV/AIDS 研究。
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英文别名 (English Synonym) |
Darunavir Ethanolate |
|
中文名称 (Chinese Name) |
达芦那韦乙醇 |
|
靶点 (Target) |
HIV Protease |
|
通路 (Pathway) |
Protease/Metabolic Enzyme |
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CAS号 (CAS NO.) |
635728-49-3 |
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分子式 (Formula) |
C29H43N3O8S |
|
分子量 (Molecular Weight) |
593.73 |
|
纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Tie Y, Boross PI, Wang YF, Gaddis L, Hussain AK, Leshchenko S, Ghosh AK, Louis JM, Harrison RW, Weber IT. High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains. J Mol Biol. 2004 Apr 23,338(2):341-52. doi: 10.1016/j.jmb.2004.02.052. PMID: 15066436.[2]Bhalekar MR, Upadhaya PG, Madgulkar AR, Kshirsagar SJ, Dube A, Bartakke US. In-vivo bioavailability and lymphatic uptake evaluation of lipid nanoparticulates of darunavir. Drug Deliv. 2016 Sep,23(7):2581-2586. doi: 10.3109/10717544.2015.1037969. Epub 2015 May 21. PMID: 25996834.
