葫芦巴或益母草来源的生物碱Trigonelline chloride具有多种生物活性。作为一种 Nrf2 抑制剂,它能阻断Nrf2依赖性蛋白酶体活性,促进胰腺癌细胞凋亡,并具有诱导铁死亡的作用。此外,该化合物还表现出抗糖尿病、抗HSV-1、抗菌及抗真菌的潜力。
|
英文别名 (English Synonym) |
Trigonelline Hydrochloride |
|
中文名称 (Chinese Name) |
盐酸葫芦巴碱；葫芦巴碱盐酸盐 |
|
靶点 (Target) |
Others |
|
通路 (Pathway) |
Anti-infection |
|
CAS号 (CAS NO.) |
6138-41-6 |
|
分子式 (Formula) |
C7H8ClNO2 |
|
分子量 (Molecular Weight) |
173.6 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Ilavenil S, Kim DH, Jeong YI, Arasu MV, Vijayakumar M, Prabhu PN, Srigopalram S, Choi KC. Trigonelline protects the cardiocyte from hydrogen peroxide induced apoptosis in H9c2 cells. Asian Pac J Trop Med. 2015 Apr,8(4):263-8. doi: 10.1016/S1995-7645(14)60328-X. PMID: 25975496.[2]Folwarczna J, Janas A, Pytlik M, Cegieła U, Śliwiński L, Krivošíková Z, Štefíková K, Gajdoš M. Effects of Trigonelline, an Alkaloid Present in Coffee, on Diabetes-Induced Disorders in the Rat Skeletal System. Nutrients. 2016 Mar 2,8(3):133. doi: 10.3390/nu8030133. PMID: 26950142, PMCID: PMC4808862.
