Lopinavir (ABT-378)是一种高效的肽模拟HIV-1蛋白酶抑制剂。它通过阻止病毒成熟以阻断其感染性,并能抑制SARS-CoV 3CLpro。
|
英文别名 (English Synonym) |
Lopinavir |
|
中文名称 (Chinese Name) |
洛匹那韦 |
|
靶点 (Target) |
HIV Protease |
|
通路 (Pathway) |
Protease/Metabolic Enzyme |
|
CAS号 (CAS NO.) |
192725-17-0 |
|
分子式 (Formula) |
C37H48N4O5 |
|
分子量 (Molecular Weight) |
628.81 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Sham HL, Kempf DJ, Molla A, Marsh KC, Kumar GN, Chen CM, Kati W, Stewart K, Lal R, Hsu A, Betebenner D, Korneyeva M, Vasavanonda S, McDonald E, Saldivar A, Wideburg N, Chen X, Niu P, Park C, Jayanti V, Grabowski B, Granneman GR, Sun E, Japour AJ, Leonard JM, Plattner JJ, Norbeck DW. ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease. Antimicrob Agents Chemother. 1998 Dec,42(12):3218-24. doi: 10.1128/AAC.42.12.3218. PMID: 9835517, PMCID: PMC106025.[2]Cvetkovic RS, Goa KL. Lopinavir/ritonavir: a review of its use in the management of HIV infection. Drugs. 2003,63(8):769-802. doi: 10.2165/00003495-200363080-00004. PMID: 12662125.
