Vinblastine sulfate是一种具有细胞毒性的生物碱,可通过抑制微管形成发挥抗肿瘤作用,并能诱导细胞自噬与凋亡,适用于多种癌症类型的研究。
| 英文别名 (English Synonym) | Vinblastine sulfate |
| 中文名称 (Chinese Name) | 硫酸长春碱 |
| 靶点 (Target) | Autophagy |
| 通路 (Pathway) | Protease/Metabolic Enzyme |
| CAS号 (CAS NO.) | 143-67-9 |
| 分子式 (Formula) | C46H60N4O13S |
| 分子量 (Molecular Weight) | 909.05 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存,有效期3年
[1] Calviño E, Tejedor MC, Sancho P, Herráez A, Diez JC. JNK and NFκB dependence of apoptosis induced by vinblastine in human acute promyelocytic leukaemia cells. Cell Biochem Funct. 2015 Jun;33(4):211-9. doi: 10.1002/cbf.3105. Epub 2015 Apr 23. PMID: 25914345.[2]Selimovic D, Badura HE, El-Khattouti A, Soell M, Porzig BB, Spernger A, Ghanjati F, Santourlidis S, Haikel Y, Hassan M. Vinblastine-induced apoptosis of melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms. Apoptosis. 2013 Aug;18(8):980-97. doi: 10.1007/s10495-013-0844-4. PMID: 23564313.[3]Bánóczi Z, Gorka-Kereskényi Á, Reményi J, Orbán E, Hazai L, Tökési N, Oláh J, Ovádi J, Béni Z, Háda V, Szántay C Jr, Hudecz F, Kalaus G, Szántay C. Synthesis and in vitro antitumor effect of vinblastine derivative-oligoarginine conjugates. Bioconjug Chem. 2010 Nov 17;21(11):1948-55. doi: 10.1021/bc100028z. Epub 2010 Oct 25. PMID: 20973492.





