6-Aminonicotinamide是一种高效烟酰胺抗代谢物,作为NADP+依赖性葡萄糖-6-磷酸脱氢酶(G6PD)的竞争性抑制剂,可特异性阻断多种细胞系统中生成NADPH的磷酸戊糖途径(PPP),导致细胞氧化应激敏感性升高及ATP耗竭;同时,该化合物能与顺铂(Cisplatin)等DNA交联类化疗药物协同作用,增强对癌细胞的杀伤效果。
| 英文别名 (English Synonym) | 6-Aminonicotinamide |
| 中文名称 (Chinese Name) | 6-氨基烟酰胺 |
| 靶点 (Target) | Dehydrogenase |
| 通路 (Pathway) | Protease/Metabolic Enzyme |
| CAS号 (CAS NO.) | 329-89-5 |
| 分子式 (Formula) | C6H7N3O |
| 分子量 (Molecular Weight) | 137.1 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存,有效期3年
[1] Tsouko E, Khan AS, White MA, Han JJ, Shi Y, Merchant FA, Sharpe MA, Xin L, Frigo DE. Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth. Oncogenesis. 2014 May 26;3(5):e103. doi: 10.1038/oncsis.2014.18. PMID: 24861463; PMCID: PMC4035695.
[2] Koutcher JA, Alfieri AA, Matei C, Meyer KL, Street JC, Martin DS. Effect of 6-aminonicotinamide on the pentose phosphate pathway: 31P NMR and tumor growth delay studies. Magn Reson Med. 1996 Dec;36(6):887-92. doi: 10.1002/mrm.1910360611. PMID: 8946354.





