Pemetrexed disodium hemipenta hydrate作为多靶点叶酸拮抗剂，可同时抑制胸苷酸合成酶（Ki=1.3 nM）、二氢叶酸还原酶（Ki=7.2 nM）及甘氨酰胺核苷酸甲酰转移酶（Ki=65 nM），通过阻断核苷酸合成途径发挥抗肿瘤作用。
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英文别名 (English Synonym) |
Pemetrexed disodium hemipenta hydrate |
|
中文名称 (Chinese Name) |
培美曲塞二钠水合物 |
|
靶点 (Target) |
Thymidylate Synthase |
|
通路 (Pathway) |
Apoptosis |
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CAS号 (CAS NO.) |
357166-30-4 |
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分子式 (Formula) |
C20H24N5Na2O8.5 |
|
分子量 (Molecular Weight) |
516.41 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于H2O |
-25~-15℃保存，有效期3年
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