Motolimod（VTX-2337；VTX-378）是一种选择性Toll样受体8（TLR8）激动剂。
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英文别名 (English Synonym) |
Motolimod (VTX-2337) |
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中文名称 (Chinese Name) |
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靶点 (Target) |
TLR |
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通路 (Pathway) |
Immunology/Inflammation |
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CAS号 (CAS NO.) |
926927-61-9 |
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分子式 (Formula) |
C28H34N4O2 |
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分子量 (Molecular Weight) |
458.6 |
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纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Lu H, Dietsch GN, Matthews MA, Yang Y, Ghanekar S, Inokuma M, Suni M, Maino VC, Henderson KE, Howbert JJ, Disis ML, Hershberg RM. VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC. Clin Cancer Res. 2012 Jan 15;18(2):499-509. doi: 10.1158/1078-0432.CCR-11-1625. Epub 2011 Nov 29. PMID: 22128302. [2] Dietsch GN, Lu H, Yang Y, Morishima C, Chow LQ, Disis ML, Hershberg RM. Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity. PLoS One. 2016 Feb 29;11(2):e0148764. doi: 10.1371/journal.pone.0148764. PMID: 26928328; PMCID: PMC4771163.
