磺胺吡啶是柳氮磺吡啶（Sulfasalazine）在体内的主要活性代谢产物，属于磺胺类抗生素。它能高效抑制卡氏肺孢子菌二氢蝶酸合成酶（DHPS，IC50=0.18 μM），并表现出抗菌、抗炎及抗风湿等多重药理活性。
|
英文别名 (English Synonym) |
Sulfapyridine |
|
中文名称 (Chinese Name) |
磺胺吡啶 |
|
靶点 (Target) |
Antibiotic |
|
通路 (Pathway) |
Microbiology/Virology |
|
CAS号 (CAS NO.) |
144-83-2 |
|
分子式 (Formula) |
C11H11N3O2S |
|
分子量 (Molecular Weight) |
249.29 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Omoteyama K, Sato T, Arito M, Sato M, Suematsu N, Kurokawa MS, Kato T. Effects of salazosulfapyridine on the profile of cell surface proteins, revealed by biotinylation of cell surface proteins and 2-dimentional electrophoresis. Biochim Biophys Acta Proteins Proteom. 2019 Jan;1867(1):47-56. doi: 10.1016/j.bbapap.2018.05.007. Epub 2018 May 9. PMID: 29753087.[2]Kim HM, An NH, Yi BH, Chae HJ, Kim HR, Moon SJ, Kim JJ, Park ST, Baek SH. Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine. Immunopharmacol Immunotoxicol. 2000 May;22(2):253-66. doi: 10.3109/08923970009016419. PMID: 10952030.
