NVP-TAE 226是ATP竞争性的粘着斑激酶FAK抑制剂，IC₅₀为5.5 nM，作用于IGF-1R、Pyk2和InsR的IC₅₀值为140 nM、3.5 nM和40 nM，具有抗肿瘤活性。

参考文献

[1] Liu TJ, LaFortune T, Honda T, et al. Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol Cancer Ther. 2007 Apr;6(4):1357-67. doi: 10.1158/1535-7163(IF:4.856).

[2] Schultze A, Decker S, Otten J, et al. TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis. Invest New Drugs. 2010 Dec;28(6):825-33. doi: 10.1007/s10637-009-9326-5(IF:2.663).

-25~-15℃保存，有效期3年。