CX-5461 (Pidnarulex)是可口服的rRNA合成抑制剂，能够抑制Pol I驱动的rRNA转录，IC₅₀为142 nM，对Pol II没有作用效果，具有抗肿瘤活性。

参考文献

[1] Drygin D, Lin A, Bliesath J, et al. Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth. Cancer Res. 2011 Feb 15;71(4):1418-30. doi: 10.1158/0008-5472.CAN-10-1728(IF:8.378).

[2] Bywater MJ, Poortinga G, Sanij E, et al. Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. Cancer Cell. 2012 Jul 10;22(1):51-65. doi: 10.1016/j.ccr.2012.05.019(IF:23.916).

-25~-15℃保存，有效期3年。