Etodolac (Lodine, AY-24236, AY24236)，又称依托度酸，是非甾体抗炎药，是COX-2选择性抑制剂，IC₅₀值为53.5 nM，在炎症部位通过阻断COX的活性抑制前列腺素的生物合成，具有抗炎、镇痛活性，临床上主要用于治疗骨关节炎和类风湿性关节炎等。

参考文献

[1] Kumagai K, et al., The COX-2 selective blocker etodolac inhibits TNFα-induced apoptosis in isolated rabbit articular chondrocytes. Int J Mol Sci. 2013 Sep 30;14(10):19705-15.

[2] Ito S, et al., Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. J Pharmacol Exp Ther. 2012 Jul;342(1):53-60.

[3] Tachibana M, et al., Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats. Pharmacology. 2003 Jun;68(2):96-104.

冰袋运输。粉末直接保存于-25~-15℃，有效期3年。建议分装后-25~-15℃干燥保存，避免反复冻融。