Rimegepant | CAS 1289023-67-1（53932ES）

Rimegepant (BMS-927711, BHV-3000, BMS927711, BHV3000)是可口服的CGRP受体拮抗剂，IC₅₀值为0.14 nM，可以缓解偏头痛。降钙素基因相关肽(CGRP)是一种在大脑神经系统周围释放的蛋白质，广泛分布于中枢神经系统，参与神经系统中疼痛传递的过程。

参考文献

[1] Luo G, et al. Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraine. J Med Chem. 2012 Dec 13;55(23):10644-51

[2] Zheng N, et al. Improved liquid-liquid extraction with inter-well volume replacement dilution workflow and its application to quantify BMS-927711 in rat dried blood spots by UHPLC-MS/MS. J Pharm Biomed Anal. 2014 Feb;89:240-50.

冰袋运输。粉末直接保存于-25~-15℃，有效期3年。建议分装后-25~-15℃干燥保存，避免反复冻融。