AM251 大麻素受体(CB1)拮抗剂|CAS 183232-66-8（53920ES）

AM251 (AM-251)是一种大麻素受体(CB1)的选择性拮抗剂，IC₅₀为8 nM。大麻素受体CB1参与多种生理过程，包括情绪食欲调节、脂质代谢、认知以及免疫等，是治疗焦虑、肥胖和神经退行性疾病等多种疾病的潜在药物靶点。

参考文献

[1] Bruno A, et al. Beyond radio-displacement techniques for identification of CB1 ligands: the first application of afluorescence-quenching assay. Sci Rep. 2014 Jan 20;4:3757.

[2] Thewke D, et al. AM-251 and SR144528 are acyl CoA:cholesterol acyltransferase inhibitors. Biochem Biophys Res Commun. 2009 Apr 3;381(2):181-6.

[3] McLaughlin PJ, et al. The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats. Psychopharmacology (Berl). 2005 Jul;180(2):286-93.

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