Apremilast (CC-10004, CC10004)，又称阿普斯特或阿普司特，是一种可口服的PDE4抑制剂，IC₅₀为74 nM，具有抗炎活性，临床上用于银屑病治疗。Apremilast通过与PDE4相结合，诱导cAMP降解，调节促炎和抗炎介质产生。

参考文献

1.Perez-Aso M, et al. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015 Sep 15;17:249.

2.Chen LG, et al. Determination of Apremilast in Rat Plasma by UPLC-MS-MS and Its Application to a Pharmacokinetic Study. J Chromatogr Sci. 2016 Sep;54(8):1336-40.

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