Decitabine (5-Aza-2'-deoxycytidine, 5-AZA-CdR, NSC 127716, NSC127716)，又称地西他滨、地西他宾、2'-脱氧-5-氮杂胞啶或2'-脱氧-5-氮杂胞啶，是脱氧胞苷类似物，一种可口服的DNA甲基转移酶抑制剂，具有潜在抗癌活性。Decitabine通过代替胞嘧啶掺入DNA，与DNA甲基转移酶形成不可逆的共价键，使DNA复制停滞在S期，进而诱导细胞周期阻滞和细胞凋亡。

参考文献

1.Nakamura M, et al. Decitabine inhibits tumor cell proliferation and up-regulates E-cadherin expression in Epstein-Barr virus-associated gastric cancer. J Med Virol. 2017 Mar;89(3):508-517.

2.Parker WB. Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer. Chem Rev. 2009 Jul;109(7):2880-93.

3.Hagemann S, et al. Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines. PLoS One. 2011 Mar 7;6(3):e17388.

4.Requena CE, et al. The nucleotidohydrolases DCTPP1 and dUTPase are involved in the cellular response to decitabine. Biochem J. 2016 Sep 1;473(17):2635-43.

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