Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa. Human TNF RII contains four cysteine-rich repeats in its ECD, which shares 58% and 56% amino acid sequence identity with the mouse and rat orthologs, respectively. Those receptors that lack DDs, like TNF RII, bind TNF Receptor-associated Factors, which transduce signals generated by activation of these receptors. Polymorphisms of the human TNFR2 gene, which result in increased expression of both membrane-bound and soluble TNF RII, have been associated with several autoimmune diseases including Crohn’s disease, systemic lupus erythematosus, and familial rheumatoid arthritis.

高纯度、高活性、低内毒素、高批间一致性

Tris-Bis PAGE

Human TNFR2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC

The purity of Human TNFR2 is greater than 90% as determined by SEC-HPLC.

ELISA Data

_{Immobilized Human TNFR2, His Tag at 0.5 μg/mL (100 μL/Well). Dose response curve for Biotinylated Human TNF alpha, His Tag with the EC50 of 16.6 ng/mL determined by ELISA.}

ELISA Data

_{Immobilized Human TNFR2, His Tag at 0.5 μg/mL (100 μL/Well). Dose response curve for Anti-TNFR2 Antibody, hFc Tag with the EC50 of 12.7 ng/mL determined by ELISA.}

-25 ~ -15℃保存，收到货之后有效期1年。
复溶后， 无菌条件下，-85 ~ -65℃保存，3个月有效期。