FLLL32 (FLLL-32; FLLL 32)是一种姜黄素小分子类似物，是JAK2/STAT3 的抑制剂，IC₅₀ < 5 μM。FLLL32可有效抑制MDA-MB-231乳腺癌和PANC-1胰腺癌细胞中STAT3的磷酸化及DNA结合活性，但不影响正常人乳腺上皮细胞或人胰腺导管上皮细胞中STAT3的磷酸化。FLLL32可显著降低各种癌细胞活力，诱导癌细胞凋亡，具有有效的抗肿瘤活性。

参考文献

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[2] Lesinski G, Bill M, Li C, et al. Abstract# 856: The small molecule curcumin analog FLLL-32 induces apoptosis in human melanoma cells via STAT3 inhibition and elicits in vivo anti-tumor activity. Cancer Research, 2009, 69(9 Supplement): 856-856.

[3] Bill MA, Fuchs JR, Li C, et al. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity. Molecular cancer, 2010, 9(1): 165.

[4] Wattenberg LW, et al. Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice.Invest New Drugs. 2012, 30(3): 916-926.

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