Cucurbitacin I（葫芦素I; Elatericin B; JSI-124; NSC-521777; JSI124; NSC521777）是一种天然的JAK2/STAT3 选择性抑制剂，可有效抑制STAT3的磷酸酪氨酸水平、DNA结合活性及其介导的基因表达，但对Src、AKT、ERK和JNK无抑制作用。JAK/STAT3信号通路在肿瘤的发生、发展中起着重要的调控作用，Cucurbitacin I可诱导癌细胞凋亡，具有有效的抗肿瘤活性。

参考文献

[1] Toru Oi, et al. STAT3 inhibitor, cucurbitacin I, is a novel therapeutic agent for osteosarcoma. 2016, 49(6):2275-2284.

[2] Kim Hyeon Jin, Kim Jin-Kyung. Antiangiogenic effects of cucurbitacin-I. 2015, 38(2):290-8.

[3] Song J, et al. Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer. Oncol Rep. 2015 Apr;33(4):1867-71.

[4] Blaskovich M A, et al. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice[J]. Cancer research, 2003, 63(6): 1270-1279.

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