Boldine是一种从山鸡椒（Litsea cubeba）根中提取的阿扑吗啡异喹啉生物碱，具有口服有效的抗氧化、抗炎和抗肿瘤活性。它通过调控ERK/AKT/GSK-3β信号通路诱导膀胱癌细胞凋亡，并通过抑制OPG/RANKL/RANK信号轴来抑制破骨细胞生成和改善骨破坏，可用于类风湿性关节炎的相关研究。

/

-25~-15℃避光保存，有效期3年。

[1] Gerhardt, D., et al. (2014). Boldine mediates antitumor effects in human bladder cancer cells by inducing G2/M phase arrest and apoptosis via modulation of ERK, AKT, and GSK-3β signaling. Urologic Oncology, 32(1), 36.e1-36.e9.

[2]Pandurangan AK, Mohebali N, Hasanpourghadi M, Looi CY, Mustafa MR, Mohd Esa N. Boldine suppresses dextran sulfate sodium-induced mouse experimental colitis: NF-κB and IL-6/STAT3 as potential targets. Biofactors. 2016 May;42(3):247-58. doi: 10.1002/biof.1267. Epub 2016 Feb 19. PMID: 26891685.