Bezisterim(HE3286;NE-3107)是天然抗炎类固醇β-AET的合成衍生物，作为一种口服有效的NF-κB部分抑制剂，它能降低IL-6和基质金属肽酶3等促炎信号，并可自由穿过血脑屏障，在溃疡性结肠炎、关节炎及实验性自身免疫性脑脊髓炎的研究中具有应用潜力；此外，其含有的炔烃基团使其可作为点击化学工具，与含叠氮化合物发生CuAAC反应。

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2~8℃避光保存，有效期3年。

[1] Treadwell, T., et al. (2009).​ The synthetic steroid derivative HE3286 attenuates NF-κB signaling and has potent anti-inflammatory effects in vitroand in vivo. Journal of Immunology, 182(1), 241-249.

[2]Nicoletti F, Philippens I, Fagone P, Ahlem CN, Reading CL, Frincke JM, Auci DL. 17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson's Disease. Parkinsons Dis. 2012;2012:969418. doi: 10.1155/2012/969418. Epub 2012 Sep 26. PMID: 23050197; PMCID: PMC3463191.