The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers.

推荐稀释比 WB:1/1000-1/2000; IHC:1/100-1/200; IF:1/50-1/200; IP:1/50

Western blot analysis of Cyclin D1 in NIH 3T3，C6 lysates using Cyclin D1 antibody.

Western blot analysis of Cyclin D1 in (1)MCF-7 lysates;(2) LnCaP lysates using Cyclin D1 antibody.

Immunohistochemistry analysis of paraffin-embedded Human bladder using Cyclin D1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunofluorescence analysis of Cyclin D1 in MCF-7 using Cyclin D1 antibody.

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