Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation, suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.

推荐稀释比 FC:5μL per test for million cells or whole blood in 100 μL volume.

Flow Cytometry analysis of HEK293T cells transiently transfected with pcDNA3.1 plasmid encoding Human IL-21 gene stained with (APC) IL-21 antibody (filled gray histogram) or (APC) mouse IgG1, κ lsoty(PE) Control (empty black histogram).

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。