Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100;IF:1/50-1/200;FC:1/50-1/100

Western blot analysis of NOTCH1 in HEK293 lysates using Notch1 antibody.

Western blot analysis of Notch1 in MCF-7, Jurkat, CEM and rat Brain lysates using Notch1 antibody.

Immunohistochemistry analysis of paraffin-embedded Human liver, using Notch1 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunofluorescent analysis of Notch1 in HeLa using Notch1 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。