Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. Each receptor contains an extracellular ligand binding domain, a transmembrane domain, and a cytoplasmic kinase domain. Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues. Seven tyrosine residues in the cytoplasmic tail of FGFR1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766.

推荐稀释比 WB:1/500-1/1000;IF:1/50-1/200;ELISA:1/10000

Western blot analysis of Phospho-FGFR1 (Tyr654) in Hela lysates using Phospho-FGFR1 (Tyr654) antibody.

EnzymeLinked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phospho-peptide (Phospho-left) and NonPhospho-peptide (Phospho-right), using FGFR1 (Phospho-Tyr654) antibody.

Immunofluorescence analysis of Phospho-FGFR1 (Tyr654) in COS7 cells using FGFR1 (Phospho-Tyr654) antibody. The picture on the right is blocked with the Phospho- peptide.

Western blot analysis of Phospho-FGFR1 (Tyr654) in 293 lysates treated with Insulin using Phospho-FGFR1 (Tyr654) antibody.The lane on the right is blocked with the Phospho- peptide.

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