CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development.

推荐稀释比 IHC:1/50-1/100

Immunohistochemistry analysis of paraffin-embedded human melanoma using CD146 antibbody. High-pressure and temperature Accel 3in1 EDTA pH 8.7 was used for antigen retrieval.

Immunohistochemistry analysis of paraffin-embedded Human endometrium tissue using CD146 antibbody. High-pressure and temperature Tris-EDTA pH 9.0 was used for antigen retrieval.

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.