The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant. [provided by RefSeq, Jul 2008]

推荐稀释比 IHC:1/50-1/100

Immunohistochemistry analysis of paraffin-embedded human melanoma using L1CAM antibbody. High-pressure and temperature GBI Accel pH 8.7 was used for antigen retrieval.

Immunohistochemistry analysis of paraffin-embedded human brain using L1CAM antibbody. High-pressure and temperature GBI Accel pH 8.7 was used for antigen retrieval.

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.