Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR) .Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small inTine, spleen and stomach.

推荐稀释比 WB:1/500-1/1000;IF:1:50/1:200

Immunocytochemistry analysis of CRTC3 (green) in Hela using CRTC3 antibody,and DAPI(blue).

Western blot analysis of CRTC3 in K562, rat Brain, C6, 3T3, Hela lysates using CRTC3 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。