Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development.

推荐稀释比 WB:1/500-1/2000;IHC:1/50-1/400;IF:1/50-1/200

Western blot analysis of CXCR4 in Jurkat lysates using CXCR4 antibody.

Immunohistochemistry analysis of paraffin-embedded Human cervical carcinoma using CXCR4 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunofluorescence analysis of CXCR4 in Jurkat using CXCR4 antibody.

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