Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of Caspase 12 in NIH/3T3 lysates using Caspase 12 antibody

Immunohistochemistry analysis of paraffin-embedded Human liver cancer using Caspase 12 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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