蛋白别名（Synonyms）

Activin receptor type-2B; ACVR2B; Activin RIIB

种属（Species)

Human/Cynomolgus

表达系统（Source）

HEK293

表达序列（Sequence）

Ser19-Thr137 (Human) / Ser40-Thr158 (Cynomolgus)

Accession

Q13705-1(Human)  /  XP_045242398.1(Cynomolgus)

标签（Tag)

C-His-Avi

分子量（Molecular Weight）

The protein has a predicted MW of 16.56 kDa. Due to glycosylation, the protein migrates to 33-43 kDa based on Bis-Tris PAGE result.

内毒素（Endotoxin）

Less than 1EU per μg by the LAL method.

纯度（Purity）

> 95% as determined by Bis-Tris PAGE;
> 95% as determined by HPLC

活性（Activity）

ELISA Data: Immobilized Human Activin A, No Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Human/Cynomolgus Activin RIIB, His Tag with the EC50 of 53.8ng/ml determined by ELISA .       
                                
ELISA Data: Immobilized Biotinylated Human/Cynomolgus Activin RIIB, His Tag at 0.5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-Activin RIIB Antibody, hFc Tag with the EC50 of 5.8ng/ml determined by ELISA.

SPR Data: Biotinylated Human/Cynomolgus Activin RIIB, His Tag captured on CM5 Chip via Anti-His Antibody can bind Human Activin A, No Tag with an affinity constant of 55.35 pM as determined in SPR assay .               
                              
SPR Data: Biotinylated Human/Cynomolgus Activin RIIB, His Tag immobilized on CM5 Chip can bind Anti-Activin RIIB Antibody, hFc Tag with an affinity constant of 6.44 pM as determined in SPR assay .

制剂（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

外观（Appearance）

冻干粉