近红外光控银纳米颗粒/卟啉MOF纳米平台用于肿瘤光动力-金属离子协同治疗

Abstract

Although metal-based agents are widely used in disease treatment, precisely controlled metal ions release is still a challenge. Here, we demonstrated a nanoplatform (PAM) to achieve on-demand activation and release of metal ions via controlling oxidation condition by near infrared (NIR) light-inducted photodynamic therapy (PDT). PAM was constructed by decorating silver nanoparticles (AgNPs) onto the porphyrinic porous coordination network (PCN) and further camouflaging with the neutrophil membrane (NM) with inflammatory targeting ability. PAM was inactive without irradiation, causing no damage to normal tissues. However, under NIR irradiation at tumor or infected tissues, PCN locally generated singlet oxygen ( 1 O 2 ), enabling AgNPs to be partly degraded to release cytotoxic Ag + for metal ions therapy (MIT). Simultaneously, the incorporated AgNPs promoted the 1 O 2 yield of PCN due to the localized electric field effect. Consequently, the NIR light-controlled interlocking interactions between AgNPs and PCN might offer a great potential for achieving controlled, precise and efficient disease treatment with reduced side-effect.