Lipoic Acid Ameliorates Lipopolysaccharide‐Induced Inflammation via Inhibition of Glycolysis in RAW264.7 Macrophages
Liduo Yue, Kai Wang, Rongyuan Wang, Linbei Lu, Lihong Fan
Journal：Immunity Inflammation and Disease
IF：3.5
DOI：10.1002/iid3.70313
PMID：41503676
Published：2026-01-08
research field：肿瘤学药物递送系统药理学生物医学工程呼吸生物学生物化学
Abstract
Anti‐inflammatory mechanism of Lipoic acid. LA and siRNA‐HIF1α inhibited the expression of HIF1α and inflammatory factors such as IL‐6, IL‐18, TNF‐α, and IL‐1β in LPS‐induced macrophages. The researchers showed in this work that the anti‐inflammation was achieved through HIF1α/glycolysis axis.
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