Antagonistic role of Al3+ against PM2.5-induced neurotoxicity via suppression of NADPH oxidase-triggered oxidative stress
Fang Liu, Cuijuan Jiang, Rongrong Liu, Bing Yan
Journal：Environmental Science-Nano
IF：9.47
DOI：10.1039/D1EN00954K
PMID：
Published：2022-01-22
research field：肿瘤学分子生物学免疫疗法免疫学结构生物学血液学
Abstract
PM2.5 is a known threat to human health. For example, PM2.5 can impair brain health by damaging neurons. In this work, a model PM2.5 particle library was employed to investigate the role of PM2.5 compositions in regulating neurotoxicity using the mouse hippocampal neuron cell line HT22 and the human neuroblastoma cell line SH-SY5Y as in vitro models. Our results demonstrated that while Pb2+, Cr(VI) and As(III) at environmentally relevant concentrations all contributed to neurotoxicity when loaded onto model PM2.5 particles, the loading of Al3+ played an antagonistic role. We further revealed that this antagonistic effect was mediated via suppression of NADPH oxidase-induced cellular reactive oxygen species when cells were exposed to model PM2.5 particles loaded with Al3+ at an environmentally relevant concentration.
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