Exosomes derived from bone marrow mesenchymal stem cells pretreated with decellularized extracellular matrix enhance the alleviation of osteoarthritis through miR-3473b/phosphatase and tensin homolog axis
Yueqi Zhang, Guobin Qi, Yuheng Yan, Chenzhong Wang, Zhe Wang, Chang Jiang, Zengxin Jiang, Tianle Ma, Chi Zhang, Zuoqin Yan
Journal：JOURNAL OF GENE MEDICINE
IF：3.5
DOI：10.1002/jgm.3510
PMID：
Published：2023-03-30
research field：分子生物学细胞生物学干细胞生物学消化生物学结构生物学再生医学骨科
Abstract
Osteoarthritis (OA) is a prevalent degenerative articular disease for which there is no effective treatment. Progress has been made in mesenchymal stem cell (MSC)‐based therapy in OA, and the efficacy has been demonstrated to be a result of paracrine exosomes from MSCs. Decellularized extracellular matrix (dECM) provides an optimum microenvironment for the expansion of MSCs. In the present study, we aimed to investigate whether exosomes isolated from bone marrow mesenchymal stem cells (BMSCs) with dECM pretreatment (dECM‐BMSC‐Exos) enhance the amelioration of OA.
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