Rhamnose Displays an Anti-Obesity Effect Through Stimulation of Adipose Dopamine Receptors and Thermogenesis
Lv Sihan, Hu Tingting, Zhang Ru, Zhou Yue, Yu Wenjing, Wang Zelin, Shi Changjie, Lian Junjiang, Huang Shichao, Pei Gang, Luan Bing
Journal：DIABETES
IF：9.34
DOI：10.2337/db22-0552
PMID：
Published：2022-12-06
research field：药理学内分泌学营养学代谢学
Abstract
The imbalance between energy intake and energy expenditure leads to the prevalence of obesity world-widely. Strategy to simultaneously limit energy intake and promote energy expenditure will serve as a powerful mean for new obesity treatment. Here, we identified Rhamnose as a non-nutritive sweetener to promote adipose thermogenesis and energy expenditure. Rhamnose promotes cAMP production and PKA activation through dopamine receptor D1 in adipose tissue. As a result, Rhamnose administration promotes UCP1-dependent thermogenesis and ameliorates obesity in mice. Thus, we have demonstrated a Rhamnose-dopamine receptor D1-PKA axis critical for thermogenesis and Rhamnose may serve as a new therapeutic molecular diet against obesity.
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