Chemical constituents of the seeds of Citrus reticulata and their bioactivity
Meng-Jue Rui, Hong-Tao Xu, Jun-Jie Yang, Gui-Xin Chou
Journal：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
IF：1.6
DOI：10.1080/10286020.2026.2625940
PMID：
Published：2026-02-09
research field：植物化学抗肿瘤药物发现天然产物化学肿瘤药理学
Abstract
Four new limonoids (1–4), reticulactone A (1), 21,23-dihydro-23-ethoxy-21-oxolimonin (2), tetrahydro-20,22-dihydroxy-21,23-diethoxy-nomilin (3), and dasycarinone B (4), as well as 11 known limonoids and one known carbolic acid, were isolated from the EtOH extract of the seeds of Citrus reticulata Blanco. The inhibitory effects of 15 limonoids (1–15) on the proliferation of HepG2 liver cancer cells were evaluated using the CCK-8 assay. Based on their structural characteristics, the results revealed that the typical limonoid compounds 2, 5, 10, and 12 exhibited stronger cytotoxicity compared to other limonoid compounds. Notably, the novel compound 2 demonstrated the strongest cytotoxic activity (IC50 = 18.24 ± 2.78 μM).
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