FPR2 agonist 2是有效且可透过血脑屏障的FPR2激动剂（对h-FPR2的EC50为0.13μM），能抑制促炎细胞因子产生、抵消线粒体功能变化，同时抑制caspase-3活性。

[1] Mastromarino M, Favia M, Schepetkin IA, Kirpotina LN, Trojan E, Niso M, Carrieri A, Leśkiewicz M, Regulska M, Darida M, Rossignolo F, Fontana S, Quinn MT, Basta-Kaim A, Leopoldo M, Lacivita E. Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders. J Med Chem. 2022 Mar 24;65(6):5004-5028. doi: 10.1021/acs.jmedchem.1c02203. Epub 2022 Mar 8. PMID: 35257581; PMCID: PMC9942528.