Deoxycorticosterone Acetate
产品介绍
Deoxycorticosterone acetate (DOCA)是一种肾上腺皮质激素、醛固酮前体及矿化皮质激素受体激动剂,可导致包括炎症、纤维化、肾小球损伤和蛋白尿在内的严重肾脏损伤。
产品性质
产品特色
|
英文别名 (English Synonym) |
Deoxycorticosterone Acetate |
|
中文名称 (Chinese Name) |
醋酸去氧皮质酮；醋酸脱氧皮质酮 |
|
靶点 (Target) |
Adrenergic Receptor |
|
通路 (Pathway) |
GPCR/G protein |
|
CAS号 (CAS NO.) |
56-47-3 |
|
分子式 (Formula) |
C23H32O4 |
|
分子量 (Molecular Weight) |
372.5 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
存储条件
-25~-15℃保存，有效期3年
COA
已发表文献
[1] Lother A, Fürst D, Bergemann S, Gilsbach R, Grahammer F, Huber TB, Hilgendorf I, Bode C, Moser M, Hein L. Deoxycorticosterone Acetate/Salt-Induced Cardiac But Not Renal Injury Is Mediated By Endothelial Mineralocorticoid Receptors Independently From Blood Pressure. Hypertension. 2016 Jan,67(1):130-8. doi: 10.1161/HYPERTENSIONAHA.115.06530. Epub 2015 Nov 9. PMID: 26553231.
